慢性阻塞性肺病恶化患者中 pertussis 的负担和影响
Archana Baburao1, Vindhya Ponnathota1, Aleena Mariam Mathew1
1Department of Respiratory Medicine, Dr. M.G.R. Educational and Research Institute, Rajarajeswari Medical College and Hospital, Bangalore.
概括
印度慢性阻塞性肺病 (COPD) 患者中常见的百日咳 (百日咳),恶化了他们的病情并增加了ICU的入院人数. 疫苗接种率非常低,这凸显了需要提高认识和进一步研究的需要.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 百日咳在印度COPD患者中很普遍,但未得到充分承认.
- 慢性肺炎恶化是一个重大的健康问题,特别是在印度.
研究的目的:
- 评估COPD急性恶化患者中 pertussis 的负担和影响.
- 评估咳感染和COPD恶化严重程度之间的相关性.
主要方法:
- 一项前性,观察性,横截面研究,对250名 COPD 患者进行了研究,这些患者入院时出现中度至严重的恶化.
- 采集口腔喉拭片用于Bordetella pertussis测试和相关的临床数据.
主要成果:
- 百日咳检测到COPD恶化患者的16.1%.
- 咳阳性患者表现出较高的COPD评估得分,更多的先前恶化,并发症 (CAD,肺高血压),较低的FEV1,运动诱导的脱和GOLD组E分类.
- 百日咳感染与急症监护室入院率的增加有关 (55%与阴性患者相比).
结论:
- 患有COPD的患者面临咳感染的风险增加,这与COPD严重程度的增加有关.
- 在COPD患者中,咳疫苗接种覆盖率很低.
- 需要进一步的多中心研究来确定COPD中百日咳的真正负担和医疗费用.
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