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在TAK1酸化中介作用下,macozinone (PBTZ169) 诱导了对结核病的先天免疫激活

Xinda Li1,2, Xiaoyi Luo1,2, Bin Wang1,2

  • 1Department of Pharmacology, Beijing Chest Hospital, Capital Medical University, Beijing, China.

mSphere
|September 22, 2025
PubMed
概括

通过TAK1酸化,PBTZ169通过上调NF-kB和MAPK通路来激活天生的免疫力. 这种免疫激活增强了抗菌活性,为治疗药物敏感和耐药结核病 (TB) 提供了一个有前途的策略.

关键词:
结核病菌菌菌的结核病菌的结核病菌.这是一种抗结核药物.免疫调节 免疫调节 免疫调节结核病后的肺部疾病.

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