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Updated: Jan 17, 2026

Monitoring the Assembly of a Secreted Bacterial Virulence Factor Using Site-specific Crosslinking
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Monitoring the Assembly of a Secreted Bacterial Virulence Factor Using Site-specific Crosslinking

Published on: December 17, 2013

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关于 Pseudomonas aeruginosa ClpP1•ClpP2 异构复合物的结构洞察力及其与 AAA+ ClpX unfoldase 的相互作用

Alireza Ghanbarpour1, Jia Jia Zhang2, Joseph H Davis2

  • 1Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, Missouri, USA.

Protein science : a publication of the Protein Society
|September 22, 2025
PubMed
概括

Pseudomonas aeruginosa ClpXP 蛋白质酶由 ClpX 和 ClpP 的对应物组成,维持细菌的蛋白质稳定. 结构分析揭示了ClpP1结合如何激活ClpP2,为新的P. aeruginosa感染疗法提供了标.

关键词:
病原体中的分子机器蛋白质溶解活性激活的方法蛋白质稳定性调节的调节.

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