营养状况对儿科囊性纤维化肺功能的影响:上埃及的回顾性多中心研究
Khaled Saad1, Eman F Gad1, Samaher F Taha1
1Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.
在患有囊性纤维化 (CF) 的埃及儿童中,营养不良很普遍,严重影响肺功能. 解决营养状况对于改善这些患者的肺部健康至关重要.
科学领域:
- 儿科 儿科 儿科
- 肺部病理学 肺部病理学
- 营养科学 营养科学
背景情况:
- 囊性纤维化 (CF) 是一种影响多个器官,特别是肺部的遗传性疾病.
- 营养状况是影响CF儿童健康结果的关键因素.
- 以前的研究表明,CF患者的营养不良和肺功能下降之间存在联系.
研究的目的:
- 评估上埃及被诊断患有囊性纤维化症的儿童的营养状况.
- 调查营养不良和这些儿童肺功能下降之间的关系.
主要方法:
- 在四个高等中心对104名患有CF的儿童 (3-18岁) 的临床数据进行了回顾性分析.
- 基于营养状态的临床特征的比较.
- 评估营养不良指标与肺功能测试结果之间的相关性.
主要成果:
- 分析的CF儿童中有72%表现出营养不良,其特点是体重较低和血清白蛋白较低.
- 营养不良儿童的生命能力 (VC) 显著下降,强迫生命能力 (FVC) 的预测值,1秒内强迫呼吸量 (FEV1) 和FEV1/FVC比率显著下降.
- 身体质量指数 (BMI) Z-score显示与关键肺功能指标的正相关性.
结论:
- 在患有囊性纤维化症的埃及儿童中,营养不良非常普遍.
- 在这个群体中,营养状况不佳和肺功能下降之间存在显著的关联.
- 旨在改善营养状况的干预措施有可能改善CF儿童的肺功能.
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