通过多网络进行代谢重编程:一种对代谢炎症和胰岛素抵抗的系统方法
Shakila Jahan Shimu1, Jawad Ul Karim Mahir2, Fardin Al Fahad Shakib2
1Department of Health Informatics, Harrisburg University of Science and Technology, 326 Market St., Harrisburg, PA 17101, USA.
Medical sciences (Basel, Switzerland)
|September 22, 2025
概括
类多提供了一种整体方法,通过向炎症和改善细胞功能来打击与肥胖相关的胰岛素抵抗和2型糖尿病. 这些天然化合物促进新陈代谢重编程,以更好地控制葡萄糖.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 营养生物化学 营养生物化学
- 细胞生物学 细胞生物学
背景情况:
- 肥胖引起的胰岛素抵抗和2型糖尿病 (T2DM) 涉及复杂的系统性问题,如炎症,氧化应激和器官功能障碍.
- 目前的治疗方法往往只针对单一的途径,忽视了相互连接的分子和细胞干扰.
- 类多被研究其应对这些多方面的挑战的潜力.
研究的目的:
- 审查类多通过哪些系统层面的机制产生代谢重编程效应.
- 综合证据,这些化合物如何增强胰岛素敏感性和β细胞功能.
- 突出类多作为肥胖引起的代谢功能障碍的整体治疗策略.
主要方法:
- 对类植物衍生的多 (hesperidin,naringenin,nobiletin,tangeretin) 的临床前研究和临床试验的综述.
- 分析分子标,包括AMPK,PI3K/Akt,NF-κB和Nrf2信号通路.
- 评估对线粒体功能和内质网膜 (ER) 应激反应的影响.
主要成果:
- 类多调节关键信号通路,增强胰岛素敏感性和减少炎症.
- 这些化合物改善线粒体生物发生,稳定膜潜力,减轻ER压力.
- 有证据表明,血糖控制显著改善,氧化/炎症标志物减少,维护β细胞功能.
结论:
- 类植物中的多具有性作用,作为整合性代谢调节剂.
- 它们重新连接新陈代谢网络并增强器官弹性的能力提供了一个整体的治疗策略.
- 这些发现支持类多在缓解肥胖引起的胰岛素抵抗根源的潜力.
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