在赤道几内亚传播的SARS-CoV-2和与Plasmodium falciparum同时感染
Diana López-Farfán1, Policarpo Ncogo2,3, Consuelo Oki4
1Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas (IPBLN, CSIC), 18016 Granada, Spain.
Infectious disease reports
|September 22, 2025
概括
这项研究调查了赤道几内亚的COVID-19 (SARS-CoV-2) 和疟疾共感染情况. 研究人员发现SARS-CoV-2的流行率很低,但疟疾的发病率很高,并观察到有限的共同感染.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 由于稀缺,异质的数据,COVID-19在非洲的影响受到争论.
- 非洲的疟疾流行性引发了对与SARS-CoV-2潜在交叉免疫性的疑问.
- 有限的研究存在SARS-CoV-2在疟疾流行非洲国家的流行和共感染.
研究的目的:
- 确定在赤道几内亚的SARS-CoV-2及其变种的流行率.
- 评估疟疾和SARS-CoV-2之间的同时感染的频率.
- 为了确定循环的SARS-CoV-2变种的起源和多样性.
主要方法:
- 对1556名志愿者进行SARS-CoV-2的抗原检测和疟疾的显微镜检测.
- 对SARS-CoV-2阳性样本的全基因组测序.
- 数据收集发生在2021年6月至10月的Bioko和Bata.
主要成果:
- 发病率为SARS-CoV-2的3.03%和疟疾的22.25%.
- 疟疾在儿童和青少年中最常见,而SARS-CoV-2则同样影响所有年龄组.
- 确定了6例 (0.37%) 疟疾和SARS-CoV-2同时感染的病例. 四十三个SARS-CoV-2基因组显示,主要是德尔塔变种,起源于欧洲.
结论:
- 这项研究提供了在疟疾流行国家中SARS-CoV-2流行率的关键初步估计.
- 已识别的循环变体,它们的起源,以及与疟疾的同时发生,为大流行影响提供了洞察力.
- 数据对于未来的流行病准备至关重要,特别是与特有病共同感染的数据.
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