进口登革热在意大利米兰:一个七年的回顾性研究
Margherita Eleonora Pieruzzi1,2, Davide Mileto3, Alessandra Helen Behring1,2
1Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, 20157 Milano, Italy.
Infectious disease reports
|September 22, 2025
概括
登革热在欧洲越来越令人担忧,从流行地区返回的旅行者经常被诊断出登革热. 早期的分子诊断对于准确识别和管理非流行性环境中的登革热病例至关重要.
科学领域:
- 医学昆虫学 医学昆虫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 登革热是一种由Aedes蚊子传播的树状病毒感染,是欧洲新出现的公共卫生问题.
- 越来越多的本土登革热疫情在非特有欧洲地区被报告.
研究的目的:
- 分析从热带流行地区返回意大利的旅行者身上出现的登革热病例.
- 了解登革热在进口病例中的临床表现,诊断方法和结果.
主要方法:
- 在路易吉·萨科医院 (2018-2024) 诊断的登革热病例的回顾性分析.
- 纳入标准:DENV 血清学或 RT-PCR 对 DENV RNA 的阳性.
- 对患者人口统计,症状,实验室发现和疾病严重程度的描述性分析.
主要成果:
- 159名旅客被诊断患有登革热;138人确诊 (86.8%) 和21人可能 (13.2%).
- 常见的症状:发烧 (100%),肌痛 (52.2%),头痛 (49.1%). 没有任何症状. 常见的实验室发现:白血病 (64.1%),血小板缺血 (53.8%).
- DENV-1和DENV-2是最常见的. 大多数病例 (94.3%) 是没有预警信号的登革热.
结论:
- 登革热是返回意大利的旅行者中发烧性疾病的重要原因.
- 建议使用分子诊断工具,因为它可能与其他树冠病毒交叉反应.
- 虽然严重的登革热在旅行者中很少见,但需要进一步的前性研究.
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