非编码RNA在急性髓性白血病中的作用
Shailendra S Maurya1, Sarita Maurya1, Sumit K Chaturvedi2
1Chromatin Architecture laboratory, Department of Hematology (SCRC), Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.
Non-coding RNA
|September 22, 2025
概括
长非编码RNAs (lncRNAs) 在急性髓性白血病 (AML) 的发展中起着至关重要的作用. 了解lncRNA的影响为AML患者提供了新的诊断和预后见解.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 急性髓性白血病 (AML) 不成比例地影响老年人,其病因复杂且不完全理解.
- 非编码RNAs (ncRNAs),包括microRNAs (miRNAs),长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs),越来越多地与AML白血病产生有关.
- 改变的ncRNA表达会影响诸如细胞增殖和细胞死亡之类的关键细胞过程,具有作为诊断和预后生物标志物的潜力.
研究的目的:
- 审查长非编码RNAs (lncRNAs) 在急性髓性白血病 (AML) 中的重要作用.
- 阐明lncRNAs如何影响AML的预后预测和诊断准确性.
- 提供对lncRNA参与AML疾病风景的全面了解.
主要方法:
- 文献综述侧重于急性髓性白血病中的非编码RNA.
- 对ncRNAs,特别是lncRNAs的诊断和预后影响进行当前研究的分析.
- 关于 lncRNAs 促进白血病发生的机制的信息综合.
主要成果:
- ncRNAs是AML病变的组成部分,影响细胞分裂,增殖和细胞亡.
- 特定的ncRNAs,特别是lncRNAs,显示出作为AML的预后生物标志物的潜力.
- 对ncRNAs的改变表达模式为AML诊断,治疗和患者随访提供了有价值的信息.
结论:
- 鉴定和研究ncRNAs,特别是lncRNAs,为AML开辟了新的治疗和诊断途径.
- lncRNAs显著影响AML的预后预测和诊断准确性.
- 对lncRNAs的进一步研究对于推进AML治疗和患者的治疗结果至关重要.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
9.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.8K
02:39lncRNA - Long Non-coding RNAs
3.5K
3.5K
01:20Types of RNA
9.1K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
9.1K
01:23Types of RNA
72.6K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
72.6K
02:53Ribosomal RNA Synthesis
14.7K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
14.7K
01:22MicroRNAs
3.8K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.8K