肥胖引起的环境和与代谢功能障碍相关的脂肪性肝病 (MASLD) 之间的探戈:转向更早检测
Harshitha Shanmugam1, Agostino Di Ciaula2, Mohamad Khalil2
1Clinica Medica "A. Murri," Department of Precision and Regenerative Medicine and Ionian Area (DiMePre- J), University of Bari Aldo Moro, Piazza G. Cesare, 11- 70124, Bari, Italy. harshithashanmugam993@gmail.com.
Internal and emergency medicine
|September 22, 2025
概括
肥胖和与代谢功能障碍相关的脂肪性肝病 (MASLD) 的患病率不断上升,需要采取紧急行动. 非侵入性诊断和个性化预防策略是中断这种有害循环的关键.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 肥胖的患病率正在全球范围内增加,推动了与代谢功能障碍相关的脂肪性肝病 (MASLD),这是最常见的慢性肝病.
- MASLD和肥胖症与过早死亡和增加的并发症有共同联系,通过肠-肝-大脑轴相互作用.
- 肥胖的环境和MASLD创造了一个反循环,需要提高对代谢疾病途径的认识.
研究的目的:
- 强调迫切需要提高对代谢疾病途径的认识,重点关注病理生理学,早期诊断,环境因素和多学科护理.
- 倡导多部门应对和护理模式转向基于风险的查,早期检测和定制干预措施.
- 引入新的非侵入性诊断工具和预防肥胖和MASLD的预防策略.
主要方法:
- 实施13C-甲素呼吸试验,以非侵入性检测亚临床肝细胞功能障碍.
- 参与欧盟资助的倡议 (FOIE GRAS,PAS GRAS,PRIMA) 研究肝脏生物能学,肠肝轴和基因环境相互作用.
- 测试基于生活方式的预防策略和远程监控的数字工具.
主要成果:
- 13C-甲氨酸呼吸试验可以在肝脏结构或生物化学变化出现之前检测肥胖患者的亚临床肝细胞功能障碍.
- 研究对肝脏生物能学,肠肝轴功能障碍以及基因与环境相互作用的先进知识.
- 基于生活方式的预防策略和综合护理模式在打击肥胖和MASLD方面表现有前途.
结论:
- 肥胖环境和MASLD之间的有害相互作用可以通过个人级别的非侵入性诊断和个性化预防以及社区级跨部门政策来中断.
- 转向基于风险的查,早期检测,量身定制的干预措施和减轻环境危害至关重要.
- 促进公平,可持续性和初级预防的综合行动对于改变全球健康,提高寿命,健康寿命和弹性至关重要.
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