丹麦重症监护室的抗生素消费,2013-2023年:全国性的时间趋势研究
Nick Frørup Meier1, Frederik Boëtius Hertz2,3, Anders Granholm1,4
1Department of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Acta anaesthesiologica Scandinavica
|September 22, 2025
概括
丹麦的重症监护病房 (ICU) 在11年内减少了21%的抗生素消费,减少了像诺基诺和卡巴胺这样的广泛抗生素的使用,但没有影响患者的治疗结果.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 公共卫生政策 公共卫生政策
背景情况:
- 在重症监护室 (ICU) 中抗生素的使用率很高,但全国消费数据很少.
- 2012年的丹麦政策旨在促进谨慎使用抗生素.
- 本研究评估了2013年至2023年丹麦ICU国家抗生素消费趋势.
研究的目的:
- 评估丹麦ICU中抗生素消费的国家趋势.
- 评估国家政策对抗生素使用的影响.
- 为了确定抗生素消费的变化是否影响了临床结果.
主要方法:
- 在丹麦 (2013-2023) 所有成年ICU的全国性观察研究.
- 包括1,121,639 ICU 病人的病日.
- 抗生素消费量以国家销售数据的定义每日剂量 (DDD) 来衡量.
主要成果:
- 总体而言,抗生素消耗减少了21% (1705至1348 DDD/1000个患者日).
- 诺基诺 (-80%),化素 (-61%) 和碳烯 (-34%) 的显著减少.
- 青素与β-乳糖酶抑制剂的使用增加 (+139%);没有观察到临床结果恶化.
结论:
- 丹麦ICU在11年内实现了实质性的抗生素消费减少.
- 降低了广泛抗生素的使用,没有产生负面的临床影响.
- 这些发现为其他医疗保健系统提供了潜在的基准.
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