针对美国的MASLD和MASH西班牙裔/拉丁裔人口:一篇评论
Nicholas A Cumpian1, Julio A Gutierrez2, William Wu3
1Department of Medicine, Harbor-UCLA Medical Center, Torrance, California.
JAMA internal medicine
|September 22, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 不成比例地影响美国的西班牙裔/拉丁裔个人,增加他们患晚期肝病的风险. 文化定制的干预措施和调整的查对于早期检测和管理至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
- 种族健康差异的差异
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 的患病率在美国西班牙裔/拉丁裔人群中最高.
- 这种人口群体面临发展代谢功能障碍相关的脂肪肝炎 (MASH),纤维化,肝硬化,肝细胞癌和肝移植需求的高风险.
- 西班牙裔/拉丁裔人口是增长最快的种族群体,MASLD的流行率比其他群体增长更快.
研究的目的:
- 突出美国西班牙裔/拉丁裔人口中MASLD和MASH所带来的重大公共卫生挑战.
- 强调需要文化意识的战略来解决健康决定因素的差异.
- 提出一个综合的临床途径,用于早期检测和管理MASLD/MASH在这个高风险群体.
主要方法:
- 在西班牙裔/拉丁裔人口中对MASLD/MASH的流行数据和风险因素的审查.
- 分析导致因素,包括心脏代谢风险,粮食不安全,获得医疗保健,语言障碍和健康素养等.
- 评估查工具,如纤维化-4指数 (FIB-4) 和考虑针对西班牙裔/拉丁裔患者的调整值.
主要成果:
- 西班牙裔/拉丁裔个人表现出与MASLD发展相关的心脏代谢和遗传风险因素的高患病率.
- 现有的FIB-4值可能缺乏足够的灵敏度,无法在西班牙裔/拉丁裔患者中准确地进行MASLD/MASH查.
- 文化定制的干预措施和心脏代谢因素的管理对于改善结果至关重要.
结论:
- MASLD和MASH对美国西班牙裔/拉丁裔个人来说是一个关键的公共卫生问题.
- 需要多方面的,文化敏感的方法来打击营养,体力活动,遗传学,研究和健康的社会决定因素的差异.
- 建议对西班牙裔/拉丁裔患者进行常规FIB-4风险分层,并调整值,以便早期检测和干预.
相关概念视频
02:55Stereotypes, Prejudice, and Discrimination
77.8K
Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who...
77.8K
01:20Mismatch Repair
5.4K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
5.4K
01:29Pharmacogenomics: Identification of New Drug Targets
121
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
121