在帕金森病中长期个性化自适应深度大脑刺激:非随机临床试验
Helen M Bronte-Stewart1, Martijn Beudel2, Jill L Ostrem3
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Standford, California.
JAMA neurology
|September 22, 2025
概括
长期适应性深度大脑刺激 (aDBS) 对帕金森病 (PD) 患者是安全有效的. 这种疗法自动调整刺激,改善症状控制,而不会增加运动障碍.
科学领域:
- 神经学 神经学
- 生物医学工程 生物医学工程
背景情况:
- 适应性深度大脑刺激 (aDBS) 为帕金森病 (PD) 提供基于神经活动的自动振幅调整.
- 对于PD患者的家用aDBS的长期安全性和有效性仍在研究中.
研究的目的:
- 评估PD患者长期aDBS的耐受性,疗效和安全性,这些患者之前在连续DBS (cDBS) 上稳定.
主要方法:
- 一项国际,开放标签,前性试验涉及68名PD参与者.
- 参与者接受了两个aDBS模式 (ST-aDBS和DT-aDBS) 的单盲交叉评估,随后进行了可选的10个月的长期随访.
- 主要终点:按时没有麻烦的动力障碍;次要终点:发送的电能总量 (TEED).
主要成果:
- 主要终点绩效目标在DT-aDBS的参与者中达到91%,在ST-aDBS的参与者中达到79%.
- 与cDBS相比,ST-aDBS显示了TEED的显著减少 (-15%).
- 在长期随访期间没有报告与设备相关的严重不良事件;探索性分析表明,在没有动力障碍的情况下,DT-aDBS的时间改善.
结论:
- 长期在家治疗的aDBS是一种耐受,有效和安全的治疗方法.
- aDBS证明了在PD治疗中改善症状管理和减少能量输送的潜力.
- 进一步的研究支持aDBS在治疗帕金森病的临床实用性.
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