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Updated: Jul 26, 2026

Observation and Quantification of Telomere and Repetitive Sequences Using Fluorescence In Situ Hybridization (FISH) with PNA Probes in Caenorhabditis elegans
10:01

Observation and Quantification of Telomere and Repetitive Sequences Using Fluorescence In Situ Hybridization (FISH) with PNA Probes in Caenorhabditis elegans

Published on: August 4, 2016

在表达光蛋白的细胞中执行端粒FISH和免疫光的灵活程序

Sarah F Clatterbuck Soper1, Paul S Meltzer2

  • 1Genetics Branch, Center for Cancer Research, National Cancer Institute.

Journal of visualized experiments : JoVE
|September 22, 2025
PubMed
概括

这项研究提出了一种新方法,将光蛋白成像与端粒光 in situ 杂交 (TelFISH) 结合起来. 这种技术在TelFISH期间保留光蛋白信号,使得先进的端粒生物学研究成为可能.

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相关概念视频

FISH - Fluorescent In-situ Hybridization02:07

FISH - Fluorescent In-situ Hybridization

Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...