一般人群中腹腔大动脉动脉瘤的危险因素:系统性审查和元分析
Pingzhen Zhang1, Chunyan Liu1, Jingjing Li1
1Department of Cardiovascular Surgery, Peking University Shenzhen Hospital, Shenzhen, China.
PloS one
|September 22, 2025
概括
男人,吸烟,高血压,脂质失调和心血管疾病显著增加腹腔大动脉瘤 (AAA) 的风险. 针对这些因素的早期干预对预防至关重要.
科学领域:
- 心血管研究研究心血管研究
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 腹腔大动脉瘤 (AAA) 是一种危及生命的疾病,破裂后死亡率高.
- 识别风险因素对于制定有效的预防策略至关重要.
研究的目的:
- 在一般人群中系统地探索和量化与腹腔大动脉动脉瘤 (AAA) 相关的风险因素.
- 为AAA风险因素提供全面的元分析概述.
主要方法:
- 在PubMed,Embase和Cochrane图书馆数据库中进行了系统的文献搜索,截至2025年5月.
- 分析包括了三项以上研究报告的因素,使用几率比率 (OR) 和随机效应模型.
- 分析的因素包括人口统计,生活方式和并发症.
主要成果:
- 男性性别 (OR:3.78),目前的/曾经的吸烟 (OR:3.39),高血压 (OR:1.31),失脂血症 (OR:1.33),冠状动脉疾病 (OR:1.81),脑血管疾病 (OR:1.32),周围血管疾病 (OR:1.67),COPD (OR:1.58),脏疾病 (OR:1.91),以及家族史 (OR:2.26) 与增加AAA风险有关.
- 糖尿病患病的风险降低 (OR:0.84).
- 高龄,酒精摄入量,癌症,超重状态或身体活动没有显著影响风险. 风险因子关联的区域差异被发现.
结论:
- AAA是一个重要的公共卫生问题,需要有针对性的干预措施.
- 早期识别和管理可更改的风险因素,如吸烟和高血压,对于AAA预防至关重要.
- 专注于已识别的风险因素的健康教育可以帮助减轻AAA的发生率.
相关概念视频
Aneurysm II: Clinical Manifestations and Diagnostic Studies
303
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
303
Aneurysm I: Introduction
370
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
370
Aneurysm III: Interprofessional Care
255
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
255
Coronary Artery Disease I: Introduction
890
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
890
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
474
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
474
Peripheral Artery Disease I: Introduction
314
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
314


