在COVID-19感染中,复发性静脉血栓栓塞和血栓分布:根据变体类型的审查
Laura Saldivar1, Tannaz Rajabi2, Wei Li2
1Department of Internal Medicine-Pediatrics, University of Rochester Medical Center, Rochester, New York, United States of America.
PloS one
|September 22, 2025
概括
肺栓塞 (PE) 凝块分布和复发性静脉血栓塞 (VTE) 率在COVID-19和非COVID-19患者之间是相似的. 然而,Omicron变种在COVID-19患者中显示了较高的外周PE流行率.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
背景情况:
- COVID-19感染与静脉血栓栓塞 (VTE) 的风险增加有关.
- 与COVID-19变种相关的PE和VTE复发的具体模式需要进一步调查.
研究的目的:
- 为了比较患有COVID-19和没有COVID-19的患者之间的PE凝块分布和复发性VTE率.
- 分析COVID-19变种 (Alpha,Delta,Omicron) 中PE分布和VTE复发的差异.
主要方法:
- 547名PE患者的回顾性图表审查.
- 将患者分为COVID-19相关的PE (CAPE) 和非COVID-19相关的PE (NCAPE) 组.
- 分析血块分布 (中心,外围,两者) 和3个月和6个月的复发性VTE.
主要成果:
- 在CAPE和NCAPE组之间,整体凝块分布模式是相似的.
- 奥米克朗变种与仅外围PE分布 (78.8%) 有显著的关联.
- 根据COVID-19状态,复发性VTE或死亡率没有显著差异.
结论:
- 虽然整体VTE风险和复发率相似,但COVID-19相关的PE凝块分布在变体之间有所不同,尤其是Omicron.
- 随着COVID-19 VTE风险和凝块模式的不断变化的性质,随着病毒变得流行,需要进行持续的研究.
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