调查咖啡/咖啡因消费和中风之间的遗传和因果关系:全基因组关联和双向门德尔随机化研究
Xin-Xing Wang1,2, Cheng-Yan Cao2,3,4, Xing-Feng Wang1,2
1Department of Neurosurgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, No. 99 Longcheng Avenue, Xiaodian District, Taiyuan, Shanxi 030032, China.
Cerebral cortex (New York, N.Y. : 1991)
|September 22, 2025
概括
这项研究表明,咖啡和咖啡因消费可能会降低中风风险. 通过使用遗传数据,研究人员发现了这些受欢迎的饮料对中风的潜在保护作用.
科学领域:
- 心血管流行病学心血管流行病学
- 营养基因组学 营养基因组学
- 遗传流行病学遗传流行病学
背景情况:
- 脑卒中对全球健康造成重大负担,现有的关于咖啡和咖啡因对中风风险的影响的研究结果不一致.
- 相互矛盾的证据表明,习惯性咖啡和咖啡因摄入对中风发生率的潜在保护性或有害影响.
研究的目的:
- 通过强大的遗传方法调查习惯性咖啡/咖啡因消费与中风风险之间的因果关系.
- 为了澄清咖啡和咖啡因对缺血性和出血性中风亚型的影响.
主要方法:
- 采用双向的双样本孟德尔随机化 (MR) 分析,利用来自大型全基因组关联研究 (GWAS) 的总结级数据.
- 鉴定了与咖啡和咖啡因消费相关的遗传变异作为工具变量.
- 分析了来自1,913,565名中风参与者的GWAS数据,1,020,314名缺血性中风,以及567,056名出血性中风.
主要成果:
- 前期的MR分析表明,基因预测的咖啡消费与中风风险降低有关 (OR=0.927,P=0.007).
- 前期的MR分析表明,基因预测的咖啡因消费与中风风险降低有关 (OR=0.831,P=0.0202).
- 反向MR分析没有发现任何证据表明中风会对咖啡或咖啡因消费产生因果影响,没有发现显著的异质性或性.
结论:
- 这些发现表明咖啡和咖啡因消费对抗中风的潜在保护作用.
- 将饮食习惯,如咖啡消费,与遗传因素相结合,对于开发有效的中风预防策略至关重要.
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