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Updated: Jan 17, 2026

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线粒体复合体I和ROS通过对立的前和后突触机制控制神经肌肉功能

Bhagaban Mallik1, Sajad A Bhat2, Xinnan Wang2

  • 1Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America.

PLoS biology
|September 22, 2025
PubMed
概括

在多索菲拉神经元中的线粒体复合体I (MCI) 枯竭会导致维持突触功能的活性氧物种 (ROS). 然而,在肌肉中,MCI枯竭和ROS导致突触损伤和神经递质受损,这与人类疾病有关.

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