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暴露于慢性间歇性缺氧的小鼠肠道微生物群的变化

Man-Lu Lu¹, Jing-Lin Wu¹, Ji-Wei Zhu¹

¹Department of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou 256603, PR China.

Journal of medical microbiology

|September 22, 2025

概括

在阻塞性睡眠呼吸暂停综合征 (OSAS) 中,慢性间歇性缺氧 (CIH) 改变了肠道微生物群,减少了有益的细菌并影响了代谢途径. 这项研究强调了肠道微生物群.

科学领域:

微生物学微生物学
睡眠医学睡眠医学
代谢障碍代谢障碍代谢障碍

背景情况:

阻塞性睡眠呼吸暂停综合征 (OSAS) 与慢性间歇性缺氧 (CIH) 有关,导致代谢和胃肠道问题等系统性并发症.
人们越来越认识到肠道微生物群在调解CIH效应中的作用,但其具体变化仍然不太了解.
了解CIH诱导的肠道微生物群变化对于阐明OSAS病原体和确定治疗点至关重要.

研究的目的:

研究CIH对肠道微生物群结构和功能通路的影响.
在OSAS.小鼠模型中分析细菌组成和代谢途径的变化.

主要方法:

雄性C57BL/6小鼠接受了6周的诺摩克西亚 (NM) 或CIH治疗.
在干预期之前和之后收集了便样本.
使用16S rRNA基因测序分析了肠道微生物组成,使用PICRUSt2.2预测了功能潜力.

主要成果:

CIH显著改变了肠道微生物群的组成,增加了*Bacteroides*和减少了*Bifidobacterium*,*Helicobacter*和*Prevotella*的丰度.
使用LEfSe和随机森林模型确定了区分微生物群组成的关键属.
功能预测显示,在CIH暴露的小鼠中,有28个显著改变的代谢途径,包括生物素,脂酸和β-氨酸代谢.

结论:

CIH诱导肠道微生物群失调并破坏短链脂肪酸产生细菌.
肠道微生物群中的这些变化与OSAS病原发生有关.
针对微生物组为CIH相关疾病提供了潜在的治疗策略.

关键词:

我们的肠道微生物群.间歇性缺氧间歇性缺氧诺尔莫克西亚 (normoxia) 是一个指标.阻塞性睡眠呼吸暂停睡眠暂停

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