内注射后抗生素预防与内炎之间的关联:系统性审查和元分析
Xiao Liu1, Ping Li, Jiawei Wang
1Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Retina (Philadelphia, Pa.)
|September 22, 2025
概括
在静脉内注射 (IVI) 之前的局部抗生素预防不能降低内炎的风险. 这次元分析发现感染率或视觉结果没有显著差异,这表明不建议进行常规预防.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 基于证据的医学基于证据的医学.
背景情况:
- 静脉内注射 (IVI) 是各种眼睛疾病的常见治疗方法.
- 内膜炎是IVI后的一个严重的潜在并发症.
- 局部抗生素预防在预防内炎的作用仍在争论中.
研究的目的:
- 系统地评估内注射后内炎的发病率,与或没有局部抗生素预防.
- 为了比较两个组之间的微生物形状和视觉结果.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行系统的文献搜索,截至2024年8月.
- 使用随机效应模型对18项研究 (3,138,778个IVI) 的元分析.
- 评估主要结局 (内炎发病率) 和次要结局 (微生物分布,最佳校正视力敏度 - - BCVA).
主要成果:
- 在局部抗生素预防和不预防组之间,内炎发病率没有显著差异 (OR1.85,P=0.2).
- 群体之间具有相似的培养阳性率 (OR 1.23,P=0.63).
- 两组之间的BCVA变化没有统计学上显著的差异 (P=0.65).
结论:
- 局部抗生素预防似乎没有减少IVI后内炎的风险.
- 目前的证据不支持局部抗生素的常规使用.
- 需要进一步考虑与抗生素使用相关的潜在风险.
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