在三胞胎症21中重新审视状鼻解剖学:CT研究
Bilal Arslan1, Mehmet Zeki Erdem2, Abdulaziz Yalinkiliç2
1Department of Pediatry, Faculty of Medicine, Van Yüzüncü Yil University.
The Journal of craniofacial surgery
|September 22, 2025
概括
与对照人群相比,患有三症21 (T21) 的患者在体积,表面积,宽度,厚度和高度方面表现出明显较小的状鼻 (SS). 型是T21患者中最常见的SS形状.
科学领域:
- 人体解剖学 解剖学 解剖学
- 放射学 放射学是一门学科.
- 遗传学 是一个遗传学.
背景情况:
- 三胞胎症21 (T21),也称为唐氏综合征,与各种面异常有关.
- 状鼻 (SS) 是头骨底部内的一个复杂的解剖结构.
- 了解T21中SS形态对于临床管理和研究至关重要.
研究的目的:
- 为了比较患有三症21 (T21) 的患者和对照组之间的状鼻 (SS) 的形态特征.
- 量化SS体积,表面积,宽度,厚度和高度的差异.
- 在T21患者中分析SS的形状变化.
主要方法:
- 从50名T21患者和60名对照组的计算机断层扫描 (CT) 图像的回顾性分析.
- 状鼻腔体积 (SSV),表面积 (SSA),宽度 (SSW),厚度 (SST) 和高度 (SSH) 的测量.
- 在T21和控制组之间对SS形状的分类和比较.
主要成果:
- 患有T21的患者表现出SSV的统计学显著减少 (约. 79%),SSA (大约为1%) 和SSA (大约为1%) 之间. 72%),SSW (大约) (大约) 在美国. 34%),SST (大约) (大约) 在美国. 50%) 和SSH (大约为 32%) 与对照组 (P <0.001) 相比.
- 在T21患者中最常见的SS形状是状 (42%),不同于对照组,其中前细胞 (33.3%) 是最常见的.
- 状鼻形状受到T21的显著影响 (P <0.001).
结论:
- 在多个形态参数上,患有21型三症的个体具有显著不发达的状鼻.
- 状鼻的特征性气动化模式在T21中发生了变化,状鼻的患病率更高.
- 这些发现突出了T21中独特的面发育模式,可能对手术规划和理解T21相关的病理有影响.
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