在多发性硬化症中持续认知衰退:研究白质损伤负载的作用,使用人工智能驱动的大脑成像方法
Vito Tota1, Astrid Mehuys2, Tanguy Vansnick3
1Department of Neurology, Centres Hospitaliers Universitaires HELORA, Mons, Belgium.
Psychiatria Danubina
|September 22, 2025
概括
白质病变负载 (WMLL) 并没有一致预测多发性硬化症 (MS) 的持续认知衰退 (SCD). 这表明需要其他成像生物标志物来理解MS患者的认知障碍.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 人工智能在医学中的应用
背景情况:
- 多发性硬化症 (MS) 是一种慢性中枢神经系统疾病,导致炎症和神经退行.
- 在MS中认知障碍可以独立于身体残疾.
- 在MS的认知衰退背后的机制尚未完全理解.
研究的目的:
- 调查白质病变负载 (WMLL) 和持续认知衰退 (SCD) 在现实世界MS队列中的关系.
- 为了利用基于人工智能 (AI) 的脑成像方法进行WMLL测量.
- 确定MS认知障碍的潜在成像生物标志物.
主要方法:
- 包括患有多发性硬化和至少三次SDMT评估和连续MRI的患者.
- 持续认知衰退 (SCD) 定义为SDMT得分的显著下降,在6个月后得到确认.
- 基于AI的细分被用于量化白质损伤负载 (WMLL).
主要成果:
- 在患有和没有SCD的患者之间,没有发现WMLL或其进展的显著差异.
- WMLL变化不是SCD的可靠预测因素.
- 患有SCD的患者更经常是男性,这表明疾病的进展更为激进.
结论:
- 在MS中持续的认知衰退 (SCD) 不总是与白质病变负载 (WMLL) 的进展相关.
- WMLL的进展可能受到与年龄相关的因素和潜在的血管病理的影响.
- 对替代成像生物标志物的进一步研究对于理解和管理MS认知障碍至关重要.
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