揭示了流感疫苗接种异质反应的基础上的动态转录和免疫细胞特征
Shirong Hui1, Ran He1, Haochang Li1
1Department of Epidemiology, Center for Global Health, School of Public Health, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education Institutions in Jiangsu Province, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing 211166, China.
Vaccine
|September 22, 2025
概括
在接种流感疫苗后,早期的基因表达和免疫细胞动态是疫苗反应的关键. 像GBP1和GBP2这样的特定基因和天真B细胞模式,与高响应者中较高的抗体标位相关.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 系统生物学 系统生物学
- 文字转录学 (Transcriptomics) 是一个学科.
背景情况:
- 季节性流感疫苗接种对于感染控制至关重要,但显示出可变的免疫反应.
- 影响个体疫苗反应变异性的分子因素仍然不太清楚.
- 这项研究调查了疫苗接种后的时间基因表达和免疫细胞动态.
研究的目的:
- 阐明与流感疫苗反应相关的时间基因表达模式.
- 分析免疫细胞动态及其与疫苗疗效的相关性.
- 为了确定疫苗反应中个体间变化的分子决定因素.
主要方法:
- 从免疫签名数据资源 (IS2) 长度转录和免疫细胞数据分析.
- 差异表达,时间序列和权重基因联合表达网络分析 (WGCNA).
- 线性混合效应模型用于评估免疫细胞子集趋势和与基因表达的关联.
主要成果:
- 在接种疫苗后的第一天观察到大多数差异性基因表达,15个基因显示出显著的动态变化.
- 干扰素刺激的基因GBP1和GBP2在高响应者中短暂上调,与抗体标位相关.
- WGCNA确定了免疫调节和细胞信号通路;在高响应者中发现了天真B细胞双相模式和JAG2关联.
结论:
- 早期的基因表达和流感疫苗接种后的动态免疫细胞变化显著塑造了免疫反应.
- 过渡调节的基因 (例如,GBP1,GBP2) 和特定的免疫细胞动态是疫苗反应的潜在关键决定因素.
- 研究结果揭示了流感疫苗反应的复杂监管网络,突出了未来研究的目标.
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