通过皮肤传递的甲中毒引起的死亡:一个病例报告和文献综述
He Yin1, Peng-Shu Zhang1, Yu Chen1
1Department of Emergency, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, China.
The Journal of international medical research
|September 22, 2025
概括
滥用ivermectin可以导致严重的中毒,即使通过皮肤应用. 这一案例突出了有记录的血液水平的致命中毒,强调了公众意识和临床医生对药物滥用的警的必要性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 临床医学 临床医学
背景情况:
- 一种抗寄生虫药物伊弗梅克丁 (Ivermectin) 已被研究出对2019年新冠肺炎疾病 (COVID-19) 的潜在疗效.
- 尽管证据有限,世卫组织建议不使用它治疗COVID-19,但滥用ivermectin导致中毒报告增加.
- 经皮肤中毒的艾弗梅克丁,其血液度已被记录,仍然基本上没有报道.
研究的目的:
- 报告一种罕见的通过皮肤输送的甲中毒致死病例.
- 为了记录患者的血ivermectin度和临床表现.
- 提高人们对滥用ivermectin及其可能导致严重不良事件的认识.
主要方法:
- 一个患者的病例报告,通过皮肤给予ivermectin过量服用.
- 血ivermectin度 (27 ng/mL) 的文件.
- 审查最近关于ivermectin毒性和潜在治疗用途的文献.
主要成果:
- 患者出现了胃肠道症状,进展为扩散性脑和内高血压.
- 尽管进行了包括输血和心肺呼吸系统支持在内的密集治疗,但该患者死亡.
- 这一案例代表了通过测量血液度的第一个经过皮肤的艾弗梅克丁中毒的记录.
结论:
- 药物过量服用,包括通过透皮途径,可导致严重的毒性和死亡.
- 提高临床医生和公众的意识对于防止滥用ivermectin至关重要.
- 未来可能使用ivermectin作为抗癌剂需要谨慎,以避免广泛过度使用和相关的中毒风险.
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