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Updated: Jan 17, 2026

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基于块化学的分子降解剂的理性发现

Junjie Wei1, Wenjing Feng2, Qingsong Chen1

  • 1Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013 Hunan, China; Hunan Key Laboratory of Small Molecules for Diagnosis and Treatment of Chronic Disease, Changsha 410013 Hunan, China; Hunan Key Laboratory of Organ Fibrosis, Changsha 410013 Hunan, China.

Drug discovery today
|September 22, 2025
PubMed
概括

分子降解剂 (MGDs) 显示出治疗前景,但面临临临床翻译挑战. 本综述详细介绍了合理设计策略和新兴技术,以加快MGD开发和临床应用.

关键词:
这就是PROTAC.区块化学 区块化学药物发现战略 药物发现战略分子降解剂分子降解剂理性发现是理性的发现

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