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相关概念视频

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

188
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
188

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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
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酸-AmB-酸-胆纳米颗粒:一种减少细胞毒性影响的方法.

Victoria Leonhard1, Dante M Beltramo1, Laura R Comini1

  • 1Centro de Excelencia en Productos y Procesos de Córdoba, Ceprocor, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas, Conicet, Argentina.

Journal of pharmaceutical sciences
|September 22, 2025
PubMed
概括
此摘要是机器生成的。

研究人员通过将脂酸与抗真菌药物安福特 B (AmB) 结合起来,开发出了新的纳米粒子. 这些稳定的Lipoate-AmB纳米颗粒显示出强大的抗真菌活性,新配方可降低药物毒性.

关键词:
氨基氨酸B (Amphotericin B) 是一种氨基氨酸.胆固醇 胆固醇 胆固醇提供药品的药物交付.脂酸酸是什么意思 脂酸是什么意思油酸小粒是油酸的小粒.物理化学表征 物理化学表征

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科学领域:

  • 纳米技术纳米技术
  • 制药科学 制药科学
  • 菌类学 菌类学是指菌类学.

背景情况:

  • 氨酸B (AmB) 是一种强效的抗真菌药物,具有有限的溶解性和显著的毒性.
  • 脂酸可以在水溶液中自我组装成稳定的纳米结构.
  • 开发有效的药物输送系统对于改善AMB的治疗指数至关重要.

研究的目的:

  • 描述由脂酸和安福特素B形成的纳米颗粒.
  • 评估这些Lipoate-AmB纳米结构的抗真菌活性和稳定性.
  • 开发一种使用胆固醇和酸的AMB的毒性较低的配方.

主要方法:

  • 在水性介质中,酸纳米结构的自发自组.
  • 在酸纳米结构中加入安福特里辛B.
  • 包括胆固醇和酸纳米粒子在内的四元复合物的形成和表征.
  • 评估开发的配方的生物活性和稳定性.

主要成果:

  • 形成具有负表面电荷的稳定Lipoate-AmB纳米粒子 (25-60nm).
  • 酸-AmB复合物表现出与商业配方可比的生物活性.
  • 形成了一个四级复合物 (酸-AmB-Oleate-Chol,~100nm),保留了抗真菌活性,毒性降低.

结论:

  • 脂酸可以有效地与安福特里辛B一起形成稳定的纳米结构.
  • 开发的Lipoate-AmB纳米颗粒为抗真菌疗法提供了一个有前途的替代方案.
  • 四级复合体在减少AmB相关的副作用方面取得了重大进展.