四基斯乙烯葡萄糖酸通过诱导Th22细胞分化促进头发再生
Lingjie Zhang1, Nana Tao1, Yuchi Chen2
1School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China.
Journal of ethnopharmacology
|September 22, 2025
概括
2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside (TSG) 通过刺激Th22细胞分化来促进头发的生长. 这种传统中医药化合物通过免疫系统调节增强毛囊再生.
科学领域:
- 皮肤病学和免疫学
- 自然产品化学 自然产品化学
- 毛囊生物学 毛囊生物学
背景情况:
- 脱发是一种常见的疾病,治疗选择有限.
- 多边形多花多花 Thunb. 含有2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside (TSG),这是一个长期用于促进头发的化合物.
- TSG在头发生长中的确切作用和机制在很大程度上是未知的.
研究的目的:
- 为了研究TSG的促进头发生长的作用.
- 阐明TSG影响头发再生的机制,重点关注Th22细胞的作用.
主要方法:
- 使用小鼠皮肤扩展剂和3D外生体培养物来选毛发生长促进剂.
- 在小鼠模型中通过皮下注射研究了TSG对头发再生的影响.
- 使用流细胞计和网络药理学分析T细胞子集,以预测机制.
- 采用免疫组织化学,免疫光和IL-22BP来验证Th22细胞的作用.
主要成果:
- 在ex vivo实验中,TSG显著促进了毛囊从泰罗基到异质的过渡.
- 在小鼠中,TSG加速了头发生长,增加了毛囊数量,增加了CD4+T细胞.
- TSG上调了毛囊中的CCR10表达,表明Th22细胞参与.
- 网络药理学和实验验证证证了Th22细胞和IL-22是TSG诱导的头发再生的关键媒介.
结论:
- 在小鼠中,TSG加速毛囊生长和再生.
- TSG通过调节T细胞子集的分布和在毛囊周围的免疫常态来促进头发的再生.
- TSG促进了Th22细胞的分化和发育,突出了其治疗脱发的治疗潜力.
相关概念视频
01:06Multipotency and Niche of Bulge Stem Cell
4.2K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.2K
01:21Stem Cell Therapy for Tissue Regeneration
4.6K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.6K
01:23Tissue Renewal without Stem Cells
2.1K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
2.1K
01:12Renewal of Skin Epidermal Stem Cells
3.0K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.0K
01:16TGF - β Signaling Pathway
10.5K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.5K