与达拉图穆马布治疗相关的急性间歇性肺炎
Navroop Momi1, Vaiishnavi Ramesh1, Aneesh Kumar Vasudevan2
1Family Medicine, Onvida Health, Yuma, Arizona, USA.
BMJ case reports
|September 22, 2025
概括
多发性骨髓瘤的CD38向疗法Daratumumab很少会导致肺损伤. 这份病例报告详细介绍了一名患有肺炎的患者,强调需要对这种不良影响进行认识.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 达拉图马布是一种针对多发性骨髓瘤的CD38向单克隆抗体.
- 虽然有效,但罕见的肺毒性是一种未被认可的不良影响.
- 早期识别和管理对于患者的治疗结果至关重要.
研究的目的:
- 在接受daratumumab的患者中报告亚急性缺氧呼吸衰竭病例.
- 突出与CD38向治疗相关的药物诱导肺炎的潜力.
- 强调在有呼吸道症状的患者中考虑这种诊断的重要性.
主要方法:
- 一位患有多发性骨髓瘤的老年女性在维护治疗中进行病例介绍. daratumumab.
- 临床评估包括成像 (双边地面玻璃不透明度) 和支气管检查.
- 对传染病和类风湿病因的诊断工作.
- 对皮质类固醇的反应和达拉图穆马布的停用.
主要成果:
- 患者出现了亚急性低氧性呼吸衰竭.
- 图像显示新出现的扩散双边地面玻璃不透明.
- 传染病和类风湿病的治疗结果是负面的.
- 经过皮质类固醇治疗和停用达拉图马布后,观察到显著改善.
结论:
- 达拉图穆马布可以诱导肺炎,这是一个罕见但严重的不良反应.
- 应考虑单克隆抗体诱导的肺损伤患者在CD38向治疗呈现呼吸系统症状.
- 及时识别和管理,包括药物停用和皮质类固醇使用,至关重要.
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