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在西班牙新确诊2型糖尿病的患者中,抗糖尿病药物的处方模式的变化:一项观察性研究
Lucia Cea-Soriano1,2, Almudena Moreno3, Marta Calonge4
1CIBERESP, Madrid, Community of Madrid, Spain.
BMJ open
|September 22, 2025
概括
在西班牙,针对2型糖尿病 (T2DM) 开处方的抗糖尿病药物数量很高,而且在不断增加. 甲胺仍然很常见,但组合疗法,特别是SGLT2抑制剂和GLP-1激动剂的组合疗法,正在增加.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病 (T2DM) 是一个日益严重的全球健康问题.
- 有效的T2DM管理依赖于及时和适当的药物治疗.
- 了解处方模式对于优化患者治疗结果至关重要.
研究的目的:
- 为了确定西班牙T2DM诊断时抗糖尿病药物处方的频率.
- 分析2018-2022年和2023-2024年期间T2DM处方模式的变化.
主要方法:
- 观察性研究设计.观察性研究设计.
- 包括来自西班牙初级保健中心新诊断T2DM的患者.
- 对抗糖尿病药物,单疗法,组合疗法和特定药物类别的处方频率的计算,与两个不同的时间段 (2018-2022 vs. 2023-2024) 的比较.
主要成果:
- 抗糖尿病药物的处方率从78.4% (2018-2022) 增加到88.9% (2023-2024).
- 单疗法处方减少,而组合疗法处方显著增加 (33.9%至42.6%).
- 处方甲福明与-葡萄糖共运输体-2 抑制剂 (SGLT2i) 和/或类似葡萄糖受体1 激动剂 (GLP1a) 成为最常见的组合,从12.8%上升到29.5%.
结论:
- 在T2DM诊断时,抗糖尿病药物的使用量很高,并且已经增加.
- 从单一疗法转向组合疗法有一个显著的转变,这是由梅特福林与SGLT2i和/或GLP1a的使用增加所驱动的.
- 这些不断变化的处方模式表明,T2DM的早期治疗策略趋向于更加密集.
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