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患有先天性腹壁缺陷的儿童的神经发育障碍:一项基于全国人口的研究

Anna Fogelström^1,2, Charlotte Skoglund³, Eva Hagel⁴

¹Division of Pediatric Surgery, Astrid Lindgren Children's Hospital, C11:33, Karolinska University Hospital, 17176, Stockholm, Sweden. anna.fogelstrom@ki.se.

Pediatric surgery international

|September 22, 2025

概括

出生时患有腹壁缺陷 (AWD) 的儿童患有自闭症谱系障碍 (ASD) 的风险更高,特别是患有腹的儿童. 然而,注意力缺陷/多动障碍 (ADHD) 的风险与同龄人相似.

科学领域:

儿科手术儿科手术
发育儿科发育儿科
公共卫生公共卫生

背景情况:

腹壁缺陷 (AWD),包括腹和胃,影响大约每4000名瑞典新生儿中的1名.
患有AWD儿童的长期神经发育结果和发病率尚未得到充分了解.

研究的目的:

为了调查神经发育障碍的风险,特别是自闭症谱系障碍 (ASD) 和注意力缺陷/多动症障碍 (ADHD),在出生时患有脑或胃的儿童中.

主要方法:

瑞典 (1997-2016) 基于人口的国家队列研究.
包括患有腹或胃的儿童,不包括染色体异常的儿童.
在每个AWD病例中匹配了10个未暴露的个体.
利用国家卫生登记处收集关于ASD和ADHD诊断的数据.

主要成果:

与未暴露的同龄人相比 (p=0.02) 的OMPHALOCELE队列显示出明显更高的ASD风险 (HR=3.51).
在AWD队列和未暴露的对照组之间没有观察到ADHD发病率的显著差异.
尽管特定子组的风险增加,神经发育障碍的总体发病率仍然相对较低.

结论:

患有AWD的儿童通常具有与同龄人相似的ADHD风险.
奥姆法洛塞尔与ASD的发病率增加有关,尽管整体发病率较低.
对AWD患者长期神经发育轨迹的进一步研究是有必要的.

关键词:

更多关于 ADHD ADHD 的文章自闭症自闭症自闭症脑外 (Exomphalos) 是一个脑外 (Exomphalos).胃裂是一种胃裂.神经发育障碍神经发育障碍脑骨是指一个大脑骨.

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