福索细菌核:生态,病变和临床影响
Shan-Shan Jiang1,2,3,4,5, Ying-Xuan Chen6,7,8,9,10, Jing-Yuan Fang11,12,13,14,15
1Division of Gastroenterology and Hepatology, Shanghai Jiao Tong University, Shanghai, China.
Nature reviews. Microbiology
|September 22, 2025
概括
一种致病生物体Fusobacterium nucleatum将口腔和肠道微生物群与结直肠癌等疾病联系起来. 了解它的作用对于开发新的诊断和治疗方法至关重要.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 翻译医学是一种翻译医学.
背景情况:
- Fusobacterium nucleatum是一种常见的口腔细菌,可以变得致病.
- 它与局部和全身性疾病有关,包括牙周病,炎症性肠病和结直肠癌.
研究的目的:
- 审查Fusobacterium nucleatum在疾病中的多方面的作用.
- 突出其在癌症发展中的致病机制.
- 为了强调其在微生物学,瘤学和翻译医学中的重要性.
主要方法:
- 本综述综合了目前关于Fusobacterium nucleatum在疾病中的作用的研究.
- 它研究了F. nucleatum促进瘤发生的机制.
- 它讨论了潜在的诊断和治疗策略.
主要成果:
- Fusobacterium nucleatum通过毒性因素,慢性炎症,免疫逃避和直接的瘤细胞相互作用,有助于瘤发生.
- 细菌的存在与癌症的进展和较差的临床结果有关.
- 在F.核和结直肠癌之间存在着强烈的联系.
结论:
- 杆菌核是一种重要的病原生物,对癌症有着重大影响.
- 进一步了解其作用对于推进疾病治疗和临床应用至关重要.
相关概念视频
Fungal Phylum Microsporidia
437
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
437
Gene Regulation in Microbial Communities: Quorum Sensing
533
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
533
The Roles of Bacteria and Fungi in Plant Nutrition
46.7K
Plants have the impressive ability to create their own food through photosynthesis. However, plants often require assistance from organisms in the soil to acquire the nutrients they need to function correctly. Both bacteria and fungi have evolved symbiotic relationships with plants that help the species to thrive in a wide variety of environments.
46.7K
Infection
11.9K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.9K
Urinary Tract Infection II: Pathophysiology
570
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
570
Cystic Fibrosis: Pathogenesis
726
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
726


