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Updated: Jan 17, 2026

Large-Scale Purification of Porcine or Bovine Photoreceptor Outer Segments for Phagocytosis Assays on Retinal Pigment Epithelial Cells
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确定PDE4作为urolithin-A的新目标,以缓解视网膜色素表皮细胞中LPS诱导的炎症

Likhitha Purna Kondapaneni1,2,3, Meenakshi Arora1,2,3,4, Erin M Scott5

  • 1The Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, AL, USA.

Pharmaceutical research
|September 22, 2025
PubMed
概括

乌罗立A (UA) 显示出作为一种新型抗炎剂的潜力,通过抑制二酶4 (PDE4) 来治疗眼部疾病. 这种肠道代谢物有效地减少了眼细胞的炎症,为现有治疗方法提供了更安全的替代方案.

关键词:
细胞因子调节 细胞因子调节它可以抑制PDE4A.视网膜色素上皮质是视网膜色素上皮质.乌罗立A是一种在cAMP信号传输中.

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Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
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