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Updated: Jan 17, 2026

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells
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缺少DNA交叉链接修复功能会增强人体细胞对 colibactin 诱导的基因毒性的敏感性

Masanobu Kawanishi1, Osamu Tsubohira2, Ai Ueshima2

  • 1Graduate School of Science, Osaka Metropolitan University, 1-2 Gakuen-cho, Naka-ku, Sakai-shi, 599-8570, Osaka, Japan. kawanishi-m@omu.ac.jp.

Genes and environment : the official journal of the Japanese Environmental Mutagen Society
|September 22, 2025
PubMed
概括

由大肠杆菌产生的可利巴克因形成跨链交叉链 (ICL) 而导致DNA损伤和细胞死亡. 细胞中ICL修复功能受损的细胞对产生大肠杆菌素的细菌敏感度增加,突出显示其具有基因毒性作用.

关键词:
在共同行动中.DNA 跨链交叉链接修复DNA的修复DNA的修复基因毒性 基因毒性

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