高剂量的psilocybin诱导了急性行为变化,而没有诱导Sprague-Dawley大鼠的条件位置偏好
Vitor Bruno1,2, Martha López-Canul2, Brandon Richardson2
1Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Brazil.
Journal of psychopharmacology (Oxford, England)
|September 23, 2025
概括
在使用条件位置偏好 (CPP) 范式的老鼠中,psilocybin (10 mg/kg) 没有产生有益的效果. 虽然在测试期间观察到行为变化,但在最后一剂剂后48小时内它们就消失了,这表明该模型中的成责任低.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
背景情况:
- 包括 псилоцибин在内的迷幻药正在引起人们的注意,作为潜在的神经精神疾病治疗方法.
- 然而,psilocybin的奖励相关影响和行为影响需要进一步调查.
研究的目的:
- 为了评估高剂量psilocybin的奖励效果.
- 为了评估psilocybin对老鼠行为的影响,使用条件位置偏好 (CPP) 范式.
主要方法:
- 鼠每隔一天接受10毫克/公斤的psilocybin或车载药物,持续8天.
- 在CPP暴露期间进行了行为评估.
- 在注射后48小时评估了奖励效应.
主要成果:
- 西没有诱导条件偏好 (CPP),这表明没有强化作用.
- 施用psilocybin改变了行为,增加了头部抽和排便,同时减少了理和养殖.
- 行为变化是短暂的,在最后一剂后48小时没有观察到差异.
结论:
- 高剂量的psilocybin (10 mg/kg) 在老鼠中没有产生CPP.
- 观察到的行为改变是暂时的,并在治疗后消失.
- 需要进一步研究各种范式和剂量,才能充分了解迷幻药的成潜力.
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