用于从水样本同时提取酸性和基本性药品的Zwitterionic基吸附剂的制备
Alberto Moral1, Francesc Borrull1, Kenneth G Furton2
1Universitat Rovira i Virgili, Department of Analytical and Organic Chemistry, Sescelades Campus, Tarragona, Spain.
Journal of separation science
|September 23, 2025
概括
研究人员使用sol-gel方法开发了新的二氧化吸附剂,用于制药的固相提取 (SPE). 最好的吸附剂实现了在环境水样中分析药物的高回收率和低检测极限.
科学领域:
- 材料科学 材料科学 材料科学
- 分析化学 分析化学
- 环境科学 环境科学
背景情况:
- 基于的吸附剂对于固相提取 (SPE) 是至关重要的.
- 开发混合模式的zwi-terionic sorbents为各种分析物提供了增强的选择性.
- 从环境矩阵中有效提取药品仍然是一个挑战.
研究的目的:
- 通过sol-gel方法合成和表征新的混合模式zwitterionic二氧化吸附剂.
- 应用这些吸附剂用于基本和酸性药品的固体相提取 (SPE).
- 验证一种在环境水样中量化药品的方法.
主要方法:
- 酸盐吸附剂的Sol-gel合成方法.
- 与zwitterionic交换组 (硫胺和四级胺) 的功能化.
- 固相提取 (SPE) 的优化和方法验证 (回收,矩阵效应,精度,检测极限).
主要成果:
- 三种自制的二氧化吸附剂被成功开发出来.
- 与2 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 硫) 氨基氧化物功能化的吸附剂显示出最佳的性能.
- 最佳的SPE条件:pH 5,可变负载体积,5毫升1%的NH4OH在MeOH中用于化.
- 明显恢复率>30%,在低ng/L范围内实现了方法检测极限.
结论:
- 开发的zwitterionic二氧化吸附剂对药品的SPE是有效的.
- 经过验证的方法允许对环境水中的药品进行敏感的量化.
- 这种方法为制药污染物的环境监测提供了一个有希望的工具.
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