之前的抵抗训练可以在心肌梗塞后对心脏进行重塑,从而对心脏进行心脏保护
Flávio André Silva1,2, Leslie Andrews Portes1, Ednei Luiz Antonio1
1Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
在小鼠心肌梗塞 (MI) 发生之前的抵抗训练 (RT) 减少了心脏病发作的大小和心脏重塑. 这种预先调节的运动可以显著地保护心脏免受心脏损伤.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 心脏康复心脏康复
背景情况:
- 在心肌梗塞 (MI) 之前,抵抗训练 (RT) 的心脏保护作用尚未得到研究.
- 在大鼠模型中研究RT对心脏心脏病后心脏重塑的影响.
研究的目的:
- 在大鼠中评估在诱导心脏病发作之前的八周RT的心脏保护作用.
- 评估RT对心脏结构,功能和心脏中风后重塑的影响.
主要方法:
- 三组老鼠:静止模拟 (SSh),静止MI (SMI) 和训练MI (TMI).
- 在MI引发之前,TMI组接受了八周的RT;对照组是久坐的.
- 动物在MI或假手术后四周被分析.
主要成果:
- 与静坐性MI (SMI) 鼠相比,训练有素的MI (TMI) 鼠表现出较小的中风大小,痕区域和心室质量.
- 尽管Ca2+处理蛋白质没有变化,但RT改善了心脏功能,由左心房区域的减少和E/A比率的正常化表明.
- 在TMI中,最大负荷 (ML) 较高,但在MI组中,VO2峰值和Vmax都降低了.
结论:
- 发作前的抵抗训练在老鼠中提供了显著的心脏保护.
- RT减轻了心脏病发作大小的进展,心肌缩和心脏病发作后的透缩功能障碍.
- 预先RT显示出作为减轻心脏损伤和重塑的预先条件化策略的潜力.
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