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定量C-反应蛋白用于区分结核和恶性多叶流液:一个横截面研究
Narayan Prakash Sharma1, Ranjan Sapkota2, Prajjwol Luitel3
1Department of General Surgery, Maharajgunj Medical Campus, Tribhuvan University, Teaching Hospital, Maharajgunj, Kathmandu, Nepal.
Indian journal of thoracic and cardiovascular surgery
|September 23, 2025
概括
胸腔液中的定量C反应蛋白 (qCRP) 可以帮助区分结核性胸腔溢出 (TPE) 和恶性胸腔溢出 (MPE). 这种简单的测试为资源有限的设置提供了具有成本效益的诊断工具.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 富含淋巴细胞的多叶膜溢出通常是由结核病和恶性瘤引起的.
- 在资源有限的环境中诊断腹腔溢液存在挑战.
- 需要一个简单的诊断测试来区分多流的原因.
研究的目的:
- 评估定量C反应蛋白 (qCRP) 的诊断实用性,以区分结核性多流血 (TPE) 与恶性多流血 (MPE).
主要方法:
- 一项涉及81名患有淋巴细胞丰富的排泄性多流的患者的横截面研究.
- 胸腔液qCRP水平的生物化学分析和病理学检查.
- 统计分析包括t-test,chi-square测试,多变量逻辑回归和ROC曲线分析.
主要成果:
- 结核性流 (TPE) 与恶性流 (MPE) (18.6 mg/L) 相比,表液中的qCRP水平显著更高 (55.5 mg/L).
- 胸腔液CRP截止值≥24.1 mg/L显示了65.9%的灵敏度和73.5%的特异性来预测TPE.
结论:
- 腹液的qCRP是区分TPE与MPE的一个有价值的工具.
- 该测试简单,快速,并且具有成本效益.
- 在具有挑战性的环境中,qCRP有助于诊断富含淋巴细胞的排泄性多流液.
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