膀癌生物标志物的全球研究趋势:图书识别分析
Alvin Tung Yong Zong1, Wei Kang Yap2
1Urology, Mersey and West Lancashire Teaching Hospitals NHS Trust, Liverpool, GBR.
Cureus
|September 23, 2025
概括
对非侵入性膀癌生物标志物的研究正在增长,从蛋白质标志物转向遗传和表观遗传的标志物. 国际合作是临床使用的关键.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 生物标志物发现发现
背景情况:
- 传统的膀癌诊断依赖于侵入性囊镜检查,需要对非侵入性诊断方法进行研究.
- 开发特定的非侵入性膀癌生物标志物是正在进行的研究的一个关键领域.
- 图书计量分析提供了对全球研究趋势和这一领域的生产率的见解.
研究的目的:
- 绘制过去二十年 (2004-2024) 膀癌生物标志物的全球研究趋势.
- 确定主要的国家,机构和作者为膀癌生物标志物研究做出贡献.
- 分析研究重点从传统生物标志物到新生物标志物的演变.
主要方法:
- 从Web of Science核心收藏中对2004年至2024年间发表的1337篇文章进行了图书统计分析.
- 使用了Bibliometrix R包和VOSviewer进行数据分析和可视化.
- 关键词分析以确定研究重点的转变.
主要成果:
- 研究产出的显著增长,在2021年达到138篇出版物的峰值.
- 中国在出版量方面领先 (516篇文章),而西班牙,英国和日本的研究影响力更高.
- 研究重点从基于蛋白质的生物标志物 (例如,NMP22,UroVysion) 转向遗传和表观遗传标志物的显著转变.
结论:
- 膀癌生物标志物研究在过去二十年中显示出了大量的增长和演变.
- 虽然中国是最具生产力的国家,但其他国家对研究的影响力更大.
- 未来的努力应优先考虑国际合作,将新兴生物标志物转化为临床实践.
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