术前维生素D的使用不会影响甲状腺切除术后低血症的发生率
Eyal Yosefof1,2,3, Dean Dudkiewicz1,3, Amit Ritter1,3
1Department of Otolaryngology - Head and Neck Surgery, Petach Tikva, Israel.
概括
在手术前补充维生素D并不能预防甲状腺手术后的低血症. 对于接受甲状腺切除术的患者,建议采用个性化支持策略,以有效管理术后的低血症.
科学领域:
- 内分泌学 在内分泌学.
- 手术并发症 手术并发症
- 营养科学 营养科学
背景情况:
- 甲状腺功能低下症是完全甲状腺切除术后经常出现的并发症.
- 维生素D缺乏在甲状腺切除术后低血症中的确切作用仍然不确定.
研究的目的:
- 评估手术前维生素D补充剂对降低甲状腺切除术后低血症发生率的影响.
主要方法:
- 一次回顾性审查比较了在 (n=728) 之前和 (n=491) 之后进行甲状腺切除术的患者,这些患者在手术前常规引入活性维生素D.
- 患者数据包括人口统计,手术前的水平,病理和手术细节.
- 监测了支持在治疗低血症方面的有效性.
主要成果:
- 手术后的水平在维生素D补充组的统计学上显示较小的下降 (-0.5 mg/dL vs -0.62 mg/dL,p=0.04).
- 短期 (<8 mg/dL),症状和长期低血症的发病率在各组之间相似 (分别为p=0.54,p=0.88,p=0.6).
- 中部部解剖和喉/胸膜毒素症与低血症有显著的联系.
结论:
- 常规的手术前维生素D补充似乎无法预防甲状腺切除术后的术后低血症.
- 建议针对患者特定因素量身定制的个性化支持策略用于管理甲状腺切除术后的低血症.
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