神经内分泌学与成相遇:新兴的药物治疗在地平线上
Anna Loften1, Mehdi Farokhnia1,2, Leandro F Vendruscolo3
1Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse, Intramural Research Program, and National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, Maryland, USA.
Journal of internal medicine
|September 23, 2025
概括
需要新的药物使用障碍治疗方法. 食和压力神经内分泌通路的向显示出开发用于酒精和物质使用障碍的新药疗法的希望.
科学领域:
- 神经内分泌学神经内分泌学
- 药理学 药理学是指药理学的学科.
- 成 药物 药物 药物 药物
背景情况:
- 酒精和其他物质使用障碍 (ASUDs) 是一个主要的全球健康问题,具有重大的社会成本.
- 目前对ASUD的药理疗法有限,特别是在酒精,烟草和阿片类药物之外的疾病中.
- 大脑-外围轴,包括肠-大脑荷尔蒙和压力通路,越来越多地被认为是ASUD中的作用.
研究的目的:
- 审查ASUD中针对神经内分泌系统的新型药物疗法的临床前和临床证据.
- 突出养和与压力相关的途径作为治疗点的潜力.
- 讨论一些特定的药物,如GLP-1, ghrelin, FGF-21,林,葡萄糖皮质类药物和矿物质皮质类药物.
主要方法:
- 现有科学文献的叙述性审查.
- 临床前 (动物) 和临床 (人类) 研究的分析.
- 专注于神经内分泌通路,涉及到食,新陈代谢和应激反应.
主要成果:
- 新出现的证据支持肠-大脑激素 (例如GLP-1, ghrelin, FGF-21, amylin) 在调节物质强化中的作用.
- 与压力相关的路径,包括下丘脑-垂体-上腺轴 (葡萄皮质类,矿物质类皮质类),都与ASUD行为有关.
- 这些神经内分泌系统代表了新型药物治疗干预的有希望的目标.
结论:
- 准与养和压力相关的神经内分泌通路为开发ASUD新疗法提供了一个有希望的途径.
- 对GLP-1激动剂和压力激素调节剂等药物的进一步研究可能会导致有效的药物疗法.
- 解决各种ASUD治疗的未满足需求对公共卫生至关重要.
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