在儿童中单独运行的脏中的盆腔尿道结合阻塞:一种不利的组合
Mathilde Grapin1, Lucas Rabaux2, Mathilde Glenisson2
1Department of Pediatric Nephrology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France, Reference Center for Inherited Renal Diseases (MARHEA), Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Acta paediatrica (Oslo, Norway : 1992)
|September 23, 2025
概括
患有单独功能脏 (SFK) 和骨盆尿路结阻塞 (PUJO) 的儿童患慢性脏病 (CKD) 的风险很高. 新生儿急性损伤 (AKI) 在SFK/PUJO患者中进一步增加了这种风险.
科学领域:
- 儿科脏病学 儿科脏病学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 功能研究 功能研究
背景情况:
- 儿童孤独功能 (SFK) 与慢性病 (CKD) 有关.
- 脏和尿路的先天性异常 (CAKUT) 在SFK中很常见.
- 盆腔尿道结口阻塞 (PUJO) 是SFK中最常见的阻塞性尿路病.
研究的目的:
- 在SFK背景下,评估PUJO手术的儿童的长期功能.
- 为了确定患有PUJO的儿科SFK患者中CKD发展的风险因素.
主要方法:
- 对患有SFK的儿童进行回顾性队列研究.
- 分组分析比较SFK与经营的PUJO,SFK没有CAKUT,SFK与其他CAKUT.
- 在随访期间评估CKD标志物和测量膜过率.
主要成果:
- 患有SFK和PUJO的儿童的CKD比例 (43%) 与没有CAKUT的SFK (12%) 相比显著更高.
- 新生儿急性损伤 (AKI) 是SFK/PUJO组后续CKD的显著预测因素 (OR 4.8).
- 由于新生儿AKI或骨扩张恶化,PUJO的手术是适用的.
结论:
- 在SFK中的PUJO与儿童慢性脏病的高发病率有关.
- 新生儿AKI的存在加剧了患有PUJO的儿科SFK患者中CKD的风险.
- 长期监测功能对于患有SFK和PUJO的儿童至关重要.
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