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Updated: Jan 17, 2026

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针对向蛋白质降解的indisulam新基质的网络驱动的识别

Andrew F Jarnuczak1, Orli Yogev2, Angelo Andres3

  • 1Discovery Sciences, R&D, AstraZeneca, Cambridge, UK. Andrew.at.bioinfo@gmail.com.

Molecular omics
|September 23, 2025
PubMed
概括

印苏拉姆是一种分子粘合剂降解剂,向DCAF15并影响细胞分裂. 研究人员使用基于网络的方法确定了30个新的indisulam目标,证实了它们的蛋白酶体依赖性降解.

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Regulated Protein Degradation02:58

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It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
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