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Updated: Jan 17, 2026

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

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定量系统毒理学预测Ivacaftor诱导的氧化应激有助于CFTR调节器肝毒性

Alan Shi1, Cole Cornwell1, Kyunghee Yang2

  • 1Department of Clinical Pharmacy, Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California, USA.

Clinical pharmacology and therapeutics
|September 23, 2025
PubMed
概括

在囊性纤维化患者中,elexacaftor/tezacaftor/ivacaftor (ETI) 可能导致肝损伤. 这项研究发现ivacaftor通过氧化应激驱动这种损伤,但剂量减少和抗氧化剂可能有助于预防它.

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