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光生物调节通过其在肠道微生物群中的双重功能来加强肌肉

Prabhat Upadhyay¹, Asmita Banstola¹, Brijesh Bhayana¹

¹Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, 50 Blossom Street, Boston, MA, 02114, USA.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|September 23, 2025

概括

适用于腹部的光生物调节疗法 (PBMT) 通过保护肠道内膜和改善肠道细菌,显著提高了耐力. 这种非侵入性治疗增强了线粒体功能,并有助于从运动压力中恢复.

科学领域:

运动生理学运动生理学
线粒体生物学线粒体生物学
微生物组研究微生物组研究

背景情况:

已知光生物调节疗法 (PBMT) 可以缓解疲劳并改善线粒体功能.
然而,当它仅适用于大腿等外围肌肉时,其对身体表现的影响是温和的.

研究的目的:

调查非侵入性腹部PBMT在增强耐力和减轻运动引起的生理压力的有效性.
探索PBMT对肠道上皮质完整性,微生物群组成和线粒体生物能学的影响.

主要方法:

受试者在无氧压力下进行了分级跑步机测试,并进行了腹部和腿部PBMT或假治疗.
评估了线粒体结构和腿部肌肉中的质量.
在便和循环样本中分析了肠道微生物群组成,短链脂肪酸 (SCFA) 水平和其他代谢物.
使用ex vivo测试和乳酸性酸性模型来评估PBMT在特定压力条件下的影响.

主要成果:

结合腹部和腿部的PBMT与假装治疗相比,与疲劳的时间相比几乎翻了一番,带来了持续的好处.
PBMT保留了线粒体晶状体和关键腿部肌肉中的质量,比假体显著增加.
腹部PBMT维持了肠道细胞系的多样性,丰富了SCFA产生细菌,减少了病原生物,并增加了诸如丁酸盐和精子胺等有益的代谢物.
在乳酸酸模型中,PBMT加速了恢复,并减少了相关的生理压力.

结论:

简短的,非侵入性腹部PBMT是一种强大的非侵入性模式,用于增强身体耐力.
PBMT有效地保护了肠道上皮质的完整性,调节了肠道微生物群,并在强度炼期间支持线粒体功能.
这些发现突显了腹部PBMT在提高表现,康复和管理与肠道失调和线粒体功能障碍相关的疾病方面的翻译潜力.

关键词:

厌氧细菌是一种厌氧细菌.强烈的运动,强烈的运动.我们的微生物群.线粒体的生物生成线粒体的生物生成通过光生物调节来进行光生物调节.

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