基于离子液体的通过皮肤递送药物系统用于生物制药
Fahmida Habib Nabila1, Muhammad Moniruzzaman2, Masahiro Goto1,3,4
1Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. m-goto@mail.cstm.kyushu-u.ac.jp.
概括
离子液体 (ILs) 通过改善皮肤透来增强蛋白质和核酸等生物物质的通过皮肤递送药物 (TDDS). 基于IL的纳米载体系统显示出通过非侵入性输送治疗糖尿病和癌症的前景.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 通过皮肤输送生物制药面临的挑战是由于皮肤的角层屏障.
- 离子液体 (ILs) 具有独特的物理化学特性,有利于药物输送.
- ILs可以充当溶剂和透增强剂,改善生物分子的溶解性,稳定性和皮肤运输.
研究的目的:
- 审查基于离子液体的透皮药物递送系统 (IL-TDDS) 的最新进展.
- 突出在纳米载体系统中ILs的应用,以提供生物制剂.
- 专注于由脂质和胆衍生的IL启用TDDS.
主要方法:
- 将IL集成到各种纳米载体系统中 (乙体,跨乙体,乳液,分散物).
- 利用ILs作为多功能材料来增强通过皮肤传输.
- 在糖尿病和癌症免疫治疗的临床前模型中评估IL-TDDS疗效.
主要成果:
- 使用基于IL的纳米载体成功通过皮肤输送胰岛素,siRNA,mRNA和其他生物药物.
- 与传统系统相比,基于IL的配方表现出高稳定性和提高药物的生物可用性.
- 在糖尿病模型中证明了长时间的血糖控制和在核酸免疫疗法中强有力的抗瘤反应.
结论:
- 离子液体是有效的多功能材料,可以克服通过皮肤传递的障碍.
- 支持IL的纳米载体系统代表了生物制药的非侵入性输送的有希望的战略.
- IL-TDDS在代谢性疾病和癌症免疫治疗中具有治疗应用的巨大潜力.
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