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Updated: Jan 17, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
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Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

Published on: September 28, 2012

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RNA/DNA结合蛋白TDP43调节DNA不匹配修复基因,对基因组稳定性有影响

Vincent E Provasek1,2, Albino Bacolla3, Suganya Rangaswamy1

  • 1Division of DNA Repair Research, Center for Neuroregeneration, Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX 77030, United States.

Nucleic acids research
|September 23, 2025
PubMed
概括

TDP43蛋白质病变影响神经退行性疾病如ALS中的DNA修复基因表达. 这项研究揭示了TDP43调节DNA不匹配修复,影响神经元健康和癌症发展.

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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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