与儿童癌症幸存者的心脏病相关的转录基因生物标志物:一个病例对照研究
Naïla Aba1,2, Gwénaël Le Teuff2,3,4, Brice Fresneau1,2,5
1Centre for Research in Epidemiology and Population Health (CESP), INSERM Unit 1018, Radiation Epidemiology team, 39 rue Camille Desmoulins Villejuif 94800, France.
European heart journal
|September 23, 2025
概括
用心脏毒性疗法治疗的儿童癌症幸存者患心脏病的风险增加. 这项研究确定了NFE2L2基因作为这些幸存者的心脏病和心力衰竭的潜在生物标志物.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 心脏病学 心脏病学
背景情况:
- 儿童癌症幸存者 (CCSs) 面临心脏病 (CDs) 的风险增加,原因是由于治疗,如 antracyclines 和放射治疗.
- 在CCS中CD发病率的个体变异性仍然不太清楚.
- 识别CD风险的生物标志物对于个性化监测和治疗策略至关重要.
研究的目的:
- 确定与儿童癌症幸存者 (CCS) 心脏病 (CD) 和心力衰竭 (HF) 发生相关的转录生物标志物.
- 研究基因表达特征在癌症治疗后预测CD和HF风险方面的潜力.
主要方法:
- 一个匹配的病例控制研究,涉及330名CCS (165名CD,165名对照).
- 在8557个基因的基因表达分析中,使用条件逻辑回归与拉索稳定方法 (百分比拉索,博拉索,子拉索) 进行了基因表达分析.
- 通过选择的基因集的交叉点和治疗剂量相互作用的调查来识别候选基因.
主要成果:
- 鉴定出NFE2L2基因是重要的生物标志物,在CD和HF病例中表达较低.
- NFE2L2表达表现出与CD (OR.16) 和HF (OR.11) 的强烈关联.
- 与单独临床变量相比,纳入NFE2L2表达改善了CD (AUC .85) 和HF (AUC .87) 的预后模型歧视.
结论:
- 基因NFE2L2是一个有前途的转录基因生物标志物,与儿童癌症幸存者的心脏病和心力衰竭有关.
- NFE2L2表达可能有助于风险分层和早期发现CCS心脏并发症.
- 需要进一步的研究来验证NFE2L2作为生物标志物,并阐明改善监测策略的潜在生物机制.
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