斑马鱼中微塑料的毒理学评估:生物化学反应和组织病理学变化
Immaculate J K1, Narmatha S M1, Jamila P1
1Suganthi Devadason Marine Research Institute, Tuticorin, India.
Journal of biochemical and molecular toxicology
|September 23, 2025
概括
斑马鱼暴露于聚乙烯微塑料 (PE MPs) 并没有对生存或生长造成损害,但导致了剂量依赖的生物积累和氧化应激,特别是在肝脏和肠道. 需要对长期生态影响进行进一步的研究.
科学领域:
- 环境毒理学环境毒理学
- 水生生态毒理学 水生生态毒理学
- 微塑料研究 微塑料研究
背景情况:
- 微塑料 (MP) 是新兴的环境污染物,对水生生态系统有潜在的风险.
- 聚乙烯 (PE) 是一种在环境中常见的塑料聚合物.
- 了解PE MPs对水生生物的毒理影响至关重要.
研究的目的:
- 研究聚乙烯微塑料 (PE MPs) 对斑马鱼 (Danio rerio) 的影响.
- 评估暴露于PEMP的斑马鱼的生存,生长,生物积累,氧化应激和病理学变化.
- 为了确定MP大小和度对这些效应的影响.
主要方法:
- 斑马鱼被暴露在PEMP的两大尺寸 (50和100微米) 中,其度不同 (0.1500微克L-1),分别为12天和24天.
- 评估的生存率,生长参数,MP生物积累 (肝脏,肠道,).
- 评估了氧化应激生物标志物 (SOD,CAT,GSH,GST,GSH-Px,LPO) 并进行了组织病理学检查 (肠道,肝脏,大脑,脏).
主要成果:
- 观察到高生存率 (>95%) 和对斑马鱼生长没有显著影响.
- 发生了PE MPs的剂量依赖生物积累,在肝脏和肠道中保持更高.
- 氧化应激和细胞损伤 (肠道亡,肝细胞脂滴) 在较高度和较长时间暴露时显而易见,脑或损伤最小.
结论:
- PE MPs可以积聚在斑马鱼组织中,诱导氧化应激,并导致组织病理损伤,特别是在消化系统中.
- 微粒体的大小会影响生物体内的分布,较小的微粒体会更广泛地分散.
- 调查结果强调需要制定减轻PM污染的战略,并进一步研究生态后果.
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