认知康复和运动对进展性多发性硬化症中大脑结构的影响:CogEx试验的结果
Francesco Romanò1, Maria A Rocca1,2,3, Elisabetta Pagani1
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy.
Journal of neurology
|September 23, 2025
概括
这项研究研究了认知康复 (CR) 和有氧运动 (EX) 对渐进性多发性硬化症中大脑变化的影响. 虽然观察到大脑总体体积减少,但CR干预显示出一些局部效应,EX影响小脑区域.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 康复医学 康复医学 康复医学
背景情况:
- 之前的研究表明,在CogEx试验中,认知康复 (CR) 增加了灰质量 (GM) 量.
- 这项研究研究了CR和有氧运动 (EX) 对区域大脑体积和白质 (WM) 完整性的联合影响.
研究的目的:
- 探讨在进展性多发性硬化症 (PMS) 患者的联合CR和EX干预后大脑体积和WM完整性的区域变化.
- 为了比较联合CR和EX对大脑结构的影响,与假冒干预相比.
主要方法:
- 73名患有信息处理速度受损的PMS患者被随机分为四组:CR+EX,CR+EX-sham,EX+CR-sham和CR-sham+EX-sham.
- 参与者接受了为期12周的干预,在基线,第12周和基线后9个月进行评估,使用结构性核磁共振成像来分析大脑体积和WM分数异构 (FA).
主要成果:
- 在Voxelwise分析中,在12周和9个月后,所有组都发现了大脑体积的普遍减少.
- 在左下回 (CR+EX与CR-sham+EX-sham) 和右小脑Crus II (EX+CR-sham与CR+EX-sham) 中观察到特定的体积变化.
- 白质FA保持稳定,没有显著的纵向组间差异.
结论:
- 结合CR+EX干预在voxel水平上显示出有限的效果,观察到大脑体积的普遍下降.
- CR干预可能会影响认知相关区域的体积变化,而EX会影响小脑运动区域.
- 方法和采样变化可能解释了与以前发现的皮质转基因体积增加的差异.
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