罗塔病毒腹监测及其分子特征在拉奇,哈克邦,2019-2023年
Vidya Sagar1, Hirendra Birua2, Rajesh Kumar3
1Department of Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, 834009, India.
Indian journal of pediatrics
|September 23, 2025
概括
轮状病毒胃肠炎在印度儿童中很常见,G2P[4]和G1P[8]基因型普遍存在. 吐增加了轮状病毒风险,而年幼的婴儿和更长的腹持续时间降低了风险.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 罗塔病毒是全球儿童严重胃肠炎的主要原因.
- 了解当地流行病学和循环菌株对于公共卫生干预至关重要.
研究的目的:
- 为了确定住院儿童中轮状病毒感染的负担.
- 为了确定急性轮状病毒胃肠炎的危险因素.
- 为了描述罗塔病毒基因型在拉奇,哈克邦.
主要方法:
- 在患有急性胃肠炎住院的5岁以下儿童的观察性研究 (2019-2023年).
- 便样本使用酶免疫测试对轮状病毒进行了测试.
- 罗塔病毒阳性样本通过逆转录聚合酶连锁反应进行基因定型.
主要成果:
- 罗塔病毒阳性率为39.4%,在冬季更高.
- 风险因素包括吐 (OR: 2.48) 和年轻年龄 (0-5个月,OR: 0.28).
- 主导的基因型是G2P[4] (35.9%),G1P[8] (30.9%) 和G3P[8] (20.4%).
结论:
- 与印度其他地区相比,兰奇的罗塔病毒阳性率更高.
- G2P[4],G1P[8],和G3P[8]是主要的轮状病毒菌株.
- 由于观察到菌株分布的变化,持续的基因型监测是必不可少的.
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