语义性痴呆症的症状前和早期表现
David J Whiteside1,2, Matthew A Rouse3, P Simon Jones1
1Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0SZ, UK.
研究人员在症状出现前几年就发现了语义性痴呆症 (SD) 的早期迹象,使用脑成像检测前叶缩. 这一发现有助于理解这种疾病.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 认知神经科学 认知神经科学
背景情况:
- 语义性痴呆症 (SD),或语义变体初级渐进性失语症,以前叶缩为特征.
- SD的进展速度比其他前性痴呆症形式慢,这表明一个长期的,鲜为人知的前性阶段.
- 早期和症状前的SD阶段在很大程度上仍然没有特征.
研究的目的:
- 调查语义性痴呆症的早期和症状前阶段.
- 为了识别具有SD的成像证据但没有正式诊断的个体.
- 为了建模纵向成像变化,并在症状发作时预测缩.
主要方法:
- 对早期SD病例和健康的志愿者随机前叶缩的分析.
- 在SD中开发和应用基于集体的结构MRI分类器.
- 使用训练有素的分类器对61,203名英国生物库参与者的评估.
主要成果:
- 在SD病例中,在症状识别前3-5年观察到明显的前叶缩.
- 该分类器准确地将SD与其他神经退行性疾病区分开来 (回忆率为0.88,精度为0.95,F1为0.91).
- 没有神经退行性诊断但有前叶缩和语义缺陷的个人在英国生物银行中被确定.
结论:
- 初始前叶缩在老年人群中很普遍,左侧和右侧的患病率相似.
- 显而易见的SD症状需要显著的缩,特别是在右侧的病例中.
- 早期的症状性SD涉及多个领域可检测的语义缺陷.
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